Quote Apaf-1 Polyclonal Antibody
Immunogen: Synthetic peptide from an N-terminal region of human Apaf-1 • Host: Rabbit • Species Reactivity: (+) Human and mouse • Application: WB • Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. It can also associate with caspase-4 and -8.
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Reference:
160780-100
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